Contact an Account ManagerSimultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by HPLC
Summary
Type: HPLC
Application #: 104480
Catalog#: 720023.40 - MN HPLC Column, Nucleosil C18, 100A, 10um, 4x250mm
Detection: fluorescence, excitation 380nm, emission 500nm
Conditions: eluent: acetonitrile - 0.1M KH2PO4 (34:66) containing 3 mM Na heptanesulphonate, adjusted to pH 4 with 1M HCl
flow rate 1ml/min
Authors: Barilero I
Source: J Chromatogr 575 (1992) 275 - 280
Details
Legend: Fig. 2. HPLC of a human plasma extracts (solid line) after administration of
100mg/m2 CPT-11, CPT = camptothecin (int. std.), dashed line pre-dose plasma
extract, peak at 4.6µin unidentified metabol